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CDC’s Pink Book meningococcal chapter

Manufacturer’s Inserts and efficacy statements:
Menactra– Efficacy was inferred from Menomune. From a study involving 72 children, Menomune demonstrates an efficacy of: (As measured by bacterial antibody)
                    Group A- 72%
                    Group C- 58%
                    Group Y- 90%
                    Group W-135- 82%

*If vaccinated before the age of 4 yrs, efficacy declines to less than 10% within 3 years.
*If vaccinated after the age of 4 yrs, efficacy declines to approximately 67% within 3 years.

The Journal of the American Medical Association published a study of the Effectiveness of a Mass Immunization Campaign Against Serogroup C Meningococcal Disease in Quebec in 2001, which came to the conclusion that:

Protection from serogroup C MCD was indicated in the first 2 years after vaccine administration (VE, 65%; 95% confidence interval [CI], 20%-84%), but not in the next 3 years (VE, 0%; 95% CI, -5% to 65%).

*VE- vaccine effectiveness

There was no evidence of protection in children younger than 2 years; all 8 MCD cases in this age group occurred in vaccinees.

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