Myth: No Rainbow, No Pot of Gold
Note: separate re-issue of part two of one of our myths blogs. We got a complaint that this one was too hard to find and link to. The easiest fix was to split it into a separate article. Thanks for your understanding.
Myth: Vaccines aren’t money makers for drug companies.
Reality: As spoken by Tom Broker about Gardasil and Merck (see page 19 of pdf)
“From a purely business point of view, they’ve been facing some real interesting challenges over the Vioxx issue and they are looking at this as the foundation and the savior of the company. Believe me, they have a huge stake in this, just as we all do.”
How profitable are vaccines? Prevnar did very well for Wyeth:
… Prevnar, which had $2.7 billion in sales last year. Prevnar is Wyeth’s No. 2 product by revenue, behind antidepressant Effexor.
Some business press projections on the potential in the vaccine market:
Gardasil sales totaled $365 million in the first quarter of 2007, helping Merck reach nearly $1 billion in total vaccine sales for the quarter, more than triple vaccine sales from a year earlier. Analyst projections have ranged up to $4 billion in annual sales for Gardasil, assuming the government mandates widespread vaccinations for girls.
Merck launched two other vaccines in 2006 – Zostavax, for the prevention of shingles, and Rotateq, for the prevention of a rotavirus that causes diarrhea in infants. Les Funtleyder, analyst for Miller Tabak, estimates that these vaccines could reach hundreds of millions of dollars in annual sales.
“Merck showed that you can make quite a bit of money with vaccines, and I think that got a lot of people’s attention,” said Funtleyder.
If vaccines have the potential to offer huge profits to pharmaceutical companies–just like other blockbuster drugs–Lipitor or Vioxx are good examples, I think we can reasonably assume that the temptation to publish ghostwritten studies, suppress unwelcome results and use Key Opinion Leaders to subtly sell product is there with vaccines, too. And vaccines offer two additional benefits, available for no other drugs: mandates and immunity from lawsuits (in the US). Who wouldn’t be tempted by a package involving a guaranteed market, and tort immunity?
There was a period, quite a long time ago now, when vaccines were not profitable. But time past is not time present. This myth is long past its sell-by date.
Myths 3.2 Chickenpox “the disease can be severe”
Filed under: CDC Watch, Parents' Pages, Vaccine Myths, Vaccine/Disease Analysis
Parents who take their children to chicken pox parties have forgotten how devastating this childhood disease can be according to vaccination experts:
“What happens if you bring your child to a chicken pox party and they’re the one in 10 who has a complication and is hospitalized?” said Dr. Jane Zucker, head of the city Health Department’s immunizations bureau.
We went back to 1951, when chickenpox afflicted millions of children every year in the U.S. to see if complications and hospitalization from chickenpox were common:
In general, chickenpox is a disease of young children and in them it usually runs an uneventful, if uncomfortable, course without leaving behind it any permanent bad effects. In very rare instances, a case of encephalitis or inflammation of the brain may occur after chickenpox, causing such symptoms as sleepiness, stiff neck, convulsions, coma, and even death.
Ordinarily, however, chickenpox is a mild though highly contagious disease…
This view of chickenpox as mild continued to exist in the U.S. for many years as this two part video snippet illustrates. Read more
Vaccine Myths 3.1: The Scourge of Childhood
Filed under: CDC Watch, Parents' Pages, Vaccine Myths, Vaccine/Disease Analysis
“…young parents of today do not remember…”
In 1974 the St. Petersburg Times wrote:
So many people are neglecting to get immunity shots that doctors fear the seven one-time scourges of childhood–polio, mumps, measles, rubella, diphtheria, lockjaw and whooping cough–may strike American communities again.
However, just six years earlier, in 1968, newspaper stories said things like this:
Although mumps is a relatively mild childhood disease, it can cause sterility when it strikes adult males.
At that time the recommendation was to give the recently developed shots to boys if they hadn’t had the mumps by the time they hit adolescence. Read more
Vaccine Myths, Round Two
Filed under: Parents' Pages, Vaccine Myths, Vaccine Science, Vaccine/Disease Analysis
Introduction: A while back, we explored some common anti-vax myths. Because in the great vaccine debates, the myths tend to outnumber the facts, we’ve decided to begin a multipart series dispelling some of the mythologies people argue over which preclude productive discussions over real issues. Below, you will find the facts behind two more common vaccine myths: herd immunity, and whether or not vaccines are profitable to pharmaceutical companies.
Myth: herd immunity isn’t real, and all the vaccine preventable diseases were declining in incidence prevaccine
Reality: vaccine induced herd immunity is a real phenomenon, and the incidences of the “diseases of childhood” (measles and mumps, for example) averaged out to be constant in the prevaccine era.
Here’s a chart showing the incidence of measles from 1912 till 1960.
Although the “death rate per cases” dropped an amazing amount, the same number of cases were happening per year on average. Read more
For the Good of the Herd
Filed under: CDC Watch, Parents' Pages, Vaccine/Disease Analysis
In an era where CDC experts are saying, “Just line up for Gardasil, and you’ll have a 70% reduced chance of getting cancer”, are parents asking any critical questions about the crystal ball gazing abilities of these experts now and in the past? Why is there talk of adding a third MMR vaccine into the childhood schedule, and also putting it into adult vaccination programs as regular boosters?
Will most people just roll up their sleeve, assuming the new ideas will have the good outcome the CDC will predict?
Most of those people won’t know, that in 1967, the CDC said: *
For centuries the measles virus has maintained a remarkably stable ecological relationship with man. The clinical disease is a characteristic syndrome of notable constancy and only moderate severity. Complications are infrequent, and, with adequate medical care, fatality is rare.
Effective use of these vaccines during the coming winter and spring should insure the eradication of measles from the United States in 1967. Read more
Where to start?
Parenthood is tough! Decisions, decisions, decisions. And here in “The Information Age”, many parents feel that there is no room for poorly informed choices for The Big Decisions. For many parents, the issue of vaccines was at one time a “no brainer”. Children were “completely” vaccinated. Everyone believed that vaccines were necessary to save your baby’s life. For the majority, vaccines were completely beyond debate. Today, many parents are questioning the safety and necessity of the large numbers of vaccines on the schedule, particularly for obscure or milder diseases. Vaccine necessity, which used to be taken for granted, has suddenly become an uncertain, debatable matter that has to be researched in depth.
What are the issues which require consideration as one steps outside the “Just do whatever your doctor tells you to do!” mindset?
- 1) the ethics of vaccine decisions in light of herd immunity
- 2) the immediate risk to the baby or child from both the diseases and the vaccines
- 3) the social stigma of possibly going against the flow and not following the recommended schedule
- 4) and the confusing, often conflicting ocean of scientific literature on the topic.
So where should a parent start? Read more
MRSA and Child Flu Deaths
Recent news stories about a link between MRSA and flu deaths in children raise some interesting questions in light of our Sisyphus series (Part I, Part II and Part III).
“Being a carrier of MRSA has increased a lot, especially among school-aged kids,” said Lyn Finelli, chief of influenza surveillance at the CDC. “And being colonized may put them at risk for a severe staph aureus infection when they get the flu.”
This particular news story blames the problem on antibiotic overuse, and, of course, recommends the flu vaccine to save children from this dangerous situation. Read more
Vaccine Information Statements For Dummies
Before any doctor gives your baby vaccines, you should be given Vaccination Information Sheets (VISs) to read.
Developed by the CDC, they inform vaccine recipients, their parents or legal representative, about the benefits and risks of vaccines. (1) Federal Law requires their use. This is a result of the National Childhood Vaccine Injury Act of 1986, 42 U.S.C. 300aa-26. (1) Before 1986, parents didn’t have any right to printed information about vaccines.
VISs sound like a good system. Parents get concise and easy to understand information on a vaccine’s risks and benefits so they can make an informed decision.
Is that really how it works? Let’s examine the nuts and bolts of VISs.
Read more
Sisyphus and the Conjugate Vaccines III
Part III of a three part series. Parts one and two can be found here and here.
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The big question with these conjugate vaccines is “What is the overall effect?”
How many fewer cases of invasive bacterial disease are happening after replacement is accounted for?
The more narrowly you look, the better these conjugate vaccines look. The more broadly you look, the more the apparent effects melt away to nothing. With Hib and “replacement disease”, if you just compare h influenza serotype B to serotype A, it would appear that killing off Hib via mass vaccination was extremely successful in the grand scheme of things. When you look at nontypeable (also known as “non capsulated”) h influenzae plus Hia and Hif, that’s when you start seeing that we’re not really any better off now than we were before the Hib conjugate vaccine. Read more
The Situation has Changed–For the Better?
Insidevaccines will be posting occasional news stories related to vaccines with commentary by our team of editors. Here we go–
In 2002 Robert Goldberg wrote:
Despite significant activity in the area of vaccine design, vaccinology and immunology, vaccine development is on the verge of becoming a brackish backwater of other biotechnology and pharmaceutical enterprises. The market for vaccines is dominated by government purchasers that drive prices down to commodity levels, the regulations for the development and production of new vaccines are mired in the 1950s and sometimes cost more than producing vaccines themselves.
Public health officials and politicians are — depending on the day — either indifferent or outright hostile to the [sic] providing private companies with incentives for investing in new vaccines for a wide range of diseases. Indeed the solution de jour is to have the government — perhaps the Department of Defense (DOD) or some offshoot of the public health service — take over the development and production of vaccines, as if a U.S. government run National Vaccine Authority could magically and efficiently construct and operate billion dollar facilities without any glitches or major disruptions. Only scientists whose only brush with business is food shopping could concoct such an idiotic scheme.